Clearance of p21 highly expressing senescent cells accelerates cutaneous wound healing.
Document Type
Article
Publication Date
1-1-2025
Original Citation
Gasek N,
Yan P,
Zhu J,
Purushothaman K,
Kim T,
Wang L,
Wang B,
Flynn W,
Sun M,
Guo C,
Huggins B,
Sharafieh R,
Zhou Y,
Parizek V,
Tchkonia T,
Kirkland J,
Wyles S,
Xu M.
Clearance of p21 highly expressing senescent cells accelerates cutaneous wound healing. Nat Aging. 2025;5(1):21-7
Keywords
JGM, Wound Healing, Cellular Senescence, Male, Female, Animals, Mice, Mice, Inbred C57BL, Mice, Transgenic, Oncogene Protein p21(ras), Gene Expression Profiling, Dermatitis
JAX Source
Nat Aging. 2025;5(1):21-7
ISSN
2662-8465
PMID
39537987
DOI
https://doi.org/10.1038/s43587-024-00755-4
Abstract
While senescent cells have detrimental roles in several contexts, they are highly heterogeneous. p16 highly expressing senescent cells have been reported to exert beneficial functions in wound healing. Here we use Xenium spatial transcriptomics to identify a distinct p21 highly expressing senescent population induced on wounding, with a pro-inflammatory profile. We find that clearing p21 highly expressing cells expedites wound closure and is partially mediated by NF-κB inhibition, thus enhancing our understanding of the multifaceted functions of senescence in tissue remodeling.