Clonal hematopoiesis in myeloid malignancies and solid tumors.
Document Type
Article
Publication Date
7-1-2025
Original Citation
Cai X,
Bowman R,
Trowbridge JJ.
Clonal hematopoiesis in myeloid malignancies and solid tumors. Nat Cancer. 2025;6(7):1133-44.
Keywords
JMG, Humans, Clonal Hematopoiesis, Neoplasms, Hematologic Neoplasms, Hematopoietic Stem Cells, Animals
JAX Source
Nat Cancer. 2025;6(7):1133-44.
ISSN
2662-1347
PMID
40681796
DOI
https://doi.org/10.1038/s43018-025-01014-0
Grant
J.J.T. is supported by the National Institutes of Health (grants R01DK118072, R01AG069010 and U01AG077925).
Abstract
Clonal hematopoiesis (CH) results from clonal expansion of hematopoietic stem cells. In specific contexts, CH is linked with an increased risk of blood cancers and mortality in individuals with solid tumors. To understand the mechanisms and clinical relevance of this association, it is crucial to explore the reciprocal relationship between CH and cancer. Here, we provide an updated summary of the mechanisms known to drive CH in blood cancers and solid tumors. In addition, we review proposed strategies to intercept CH and examine their impact on solid tumor-directed therapies, including immunostimulatory therapies.