A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy.
Document Type
Article
Publication Date
4-3-2025
Original Citation
Benvenisty N,
Draper J,
Gokhale P,
Healy L,
Hewitt Z,
Hursh D,
Hodgson A,
Ludwig T,
Mah N,
McClelland S,
Mennecozzi M,
Merkle F,
Mountford J,
Pera M,
Prigione A,
Rodriguez T,
Rossi A,
Rouhani F,
Saeb-Parsy K,
Selfa Aspiroz L,
Shakiba N,
Spits C,
Tonge P,
Barbaric I.
A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy. Cell Stem Cell. 2025;32(4):508-12.
Keywords
JMG, Humans, Pluripotent Stem Cells, Cell- and Tissue-Based Therapy, Genetic Variation
JAX Source
Cell Stem Cell. 2025;32(4):508-12.
ISSN
1875-9777
PMID
40185071
DOI
https://doi.org/10.1016/j.stem.2025.03.003
Abstract
Human pluripotent stem cell (hPSC)-based therapies offer promise but pose potential risks due to culture-acquired genetic variants, some of which have been linked with cancer. An international workshop addressed these concerns, highlighting the need for improved strategies to stratify variants and chart a path toward definitive guidelines in hPSC-based therapy.