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Submissions from 2021

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The Mutant Mouse Resource and Research Center (MMRRC): the NIH-supported National Public Repository and Distribution Archive of Mutant Mouse Models in the USA., James Amos-Landgraf, Craig Franklin, Virginia Godfrey, Franziska Grieder, Kristin Grimsrud, Ian Korf, Cathleen Lutz, Terry Magnuson, Oleg Mirochnitchenko, Samit Patel, Laura G Reinholdt, and K C Kent Lloyd

The AGE Presents Introduction to Geroscience video lecture series., Alessandro Bitto, Mitchell B Lee, Cristal M Hill, Ron Korstanje, and Matt Kaeberlein

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Inactive rhomboid proteins RHBDF1 and RHBDF2 (iRhoms): a decade of research in murine models., Lisa M. Burzenski, Benjamin E. Low, Vivek Kohar, Leonard D. Shultz, Michael V. Wiles, and Vishnu Hosur

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Antibody Responses to SARS-CoV-2 After Infection or Vaccination in Children and Young Adults With Inflammatory Bowel Disease., Joelynn Dailey, Lina Kozhaya, Mikail Dogan, Dena Hopkins, Blaine Lapin, Katherine Herbst, Michael Brimacombe, Kristen Grandonico, Fatih Karabacak, John Schreiber, Bruce Tsan-Liang Liang, Juan C Salazar, Derya Unutmaz, and Jeffrey S Hyams

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Distinct toll-like receptor signaling in the salamander response to tissue damage., Ryan J Debuque, Sergej Nowoshilow, Katya E Chan, Nadia Rosenthal, and James W Godwin

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Deep learning trained on hematoxylin and eosin tumor region of Interest predicts HER2 status and trastuzumab treatment response in HER2+ breast cancer., Saman Farahmand, Aileen I Fernandez, Fahad Shabbir Ahmed, David L Rimm, Jeffrey Chuang, Emily Reisenbichler, and Kourosh Zarringhalam

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Oral anaphylaxis to peanut in a mouse model is associated with gut permeability but not with Tlr4 or Dock8 mutations., Jake A Gertie, Biyan Zhang, Elise G Liu, Laura R Hoyt, Xiangyun Yin, Lan Xu, Lauren L Long, Arielle Soldatenko, Uthaman Gowthaman, Adam Williams, and Stephanie C Eisenbarth

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Reactome and the Gene Ontology: Digital convergence of data resources., Benjamin M Good, Kimberly Van Auken, David P. Hill, Huaiyu Mi, Seth Carbon, James P Balhoff, Laurent-Philippe Albou, Paul D Thomas, Christopher J Mungall, Judith A. Blake, and Peter D'Eustachio

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Sex Differences in the Brain Transcriptome Related to Alcohol Effects and Alcohol Use Disorder., Robert Hitzemann, Susan E Bergeson, Ari E Berman, Jason A. Bubier, Elissa J Chesler, Deborah A Finn, Matthew Hein, Paula Hoffman, Andrew Holmes, Brent R Kisby, Denesa Lockwood, Kerrie H Lodowski, Michelle McManus, Julie A Owen, Angela R Ozburn, Praneetha Panthagani, Igor Ponomarev, Laura Saba, Boris Tabakoff, Aashlesha Walchale, Robert W Williams, and Tamara J Phillips

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A novel clinically relevant graft-versus-leukemia model in humanized mice., Bei Jia, Chenchen Zhao, Michael Bayerl, Hiroko Shike, David F Claxton, W Christopher Ehmann, Shin Mineishi, Todd D Schell, Pan Zheng, Yi Zhang, Leonard D. Shultz, K Sandeep Prabhu, Robert F Paulson, and Hong Zheng

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Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response., Kevin C Johnson, Kevin J Anderson, Elise T Courtois, Amit D Gujar, Floris P Barthel, Frederick S Varn, Diane Luo, Martine Seignon, Eunhee Yi, Hoon Kim, Marcos R H Estecio, Dacheng Zhao, Ming Tang, Nicholas E Navin, Rahul Maurya, Chew Yee Ngan, Niels Verburg, Philip C de Witt Hamer, Ketan Bulsara, Michael Samuels, Sunit Das, Paul Robson, and Roel G W Verhaak

The Jackson Laboratory Nathan Shock Center: impact of genetic diversity on aging., Ron Korstanje, Luanne L. Peters, Laura Robinson, Stephen D Krasinski, and Gary A Churchill

Macrophages in dermatology: pathogenic roles and targeted therapeutics., Drew Kuraitis, Nadia Rosenthal, Erin Boh, and Elizabeth McBurney

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Mako: A Graph-based Pattern Growth Approach to Detect Complex Structural Variants., Jiadong Lin, Xiaofei Yang, Walter Kosters, Tun Xu, Yanyan Jia, Songbo Wang, Qihui Zhu, Mallory Ryan, Li Guo, Chengsheng Zhang, Charles Lee, Scott E Devine, Evan E Eichler, Kai Ye, and Human Genome Structural Variation Consortium

Association of Coding Variants in Hydroxysteroid 17-beta Dehydrogenase 14 (HSD17B14) with Reduced Progression to End Stage Kidney Disease in Type 1 Diabetes., Josyf Mychaleckyj, Erkka Valo, Takaharu Ichimura, Tarunveer Ahluwalia, Christian Dina, Rachel Miller, Ivan Shabalin, Beata Gyorgy, JingJing Cao, Suna Onengut-Gumuscu, Eiichiro Satake, Adam Smiles, Jani Haukka, David-Alexandre Tregouet, Tina Costacou, Kristina O'Neil, Andrew Paterson, Carol Forsblom, Hillary Keenan, Marcus Pezzolesi, Marlon Pragnell, Andrzej Galecki, Stephen Rich, Niina Sandholm, Ronald Klein, Barbara Klein, Katalin Susztak, Trevor Orchard, Ron Korstanje, George King, Samy Hadjadj, Peter Rossing, Joseph Bonventre, Per-Henrik Groop, James Warram, and Andrzej Krolewski

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Fasting blood glucose as a predictor of mortality: Lost in translation., Dushani L Palliyaguru, Eric J Shiroma, John K Nam, Eleonora Duregon, Camila Vieira Ligo Teixeira, Nathan L Price, Michel Bernier, Simonetta Camandola, Kelli L Vaughan, Ricki J Colman, Andrew Deighan, Ron Korstanje, Luanne L. Peters, Stephanie L Dickinson, Keisuke Ejima, Eleanor M Simonsick, Lenore J Launer, Chee W Chia, Josephine Egan, David B Allison, Gary A Churchill, Rozalyn M Anderson, Luigi Ferrucci, Julie A Mattison, and Rafael de Cabo

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Annotated expression and activity data for murine recombinase alleles and transgenes: the CrePortal resource., Michelle N Perry, Constance M. Smith, Hiroaki Onda, Martin Ringwald, Stephen A. Murray, and Cynthia Smith

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Multiple genome viewer (MGV): a new tool for visualization and comparison of multiple annotated genomes., Joel E Richardson, Richard M. Baldarelli, and Carol J Bult

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A systems approach using Diversity Outbred mice distinguishes the cardiovascular effects and genetics of circulating GDF11 from those of its homolog, myostatin., Abigail E Starcher, Kristen Peissig, James B Stanton, Gary A Churchill, Dunpeng Cai, Joshua T Maxwell, Arthur Grider, Kim Love, Shi-You Chen, Amanda E Coleman, Emma Strauss, and Robert Pazdro

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Actinomycin D targets NPM1c-primed mitochondria to restore PML-driven senescence in AML therapy., Hsin-Chieh Wu, Domitille Rerolle, Caroline Berthier, Rita Hleihel, Takashi Sakamoto, Samuel Quentin, Shirine Benhenda, Claudia Morganti, Chengchen Wu, Lidio Conte, Sylvie Rimsky, Marie Sebert, Emmanuelle Clappier, Sylvie Souquere, Stephanie Gachet, Jean Soulier, Sylvere Durand, Jennifer J. Trowbridge, Paule Benit, Pierre Rustin, Hiba El Hajj, Emmanuel Raffoux, Lionel Ades, Raphael Itzykson, Herve Dombret, Pierre Fenaux, Olivier Espeli, Guido Kroemer, Lorenzo Brunetti, Tak W Mak, Valerie Lallemand-Breitenbach, Ali Bazarbachi, Brunangelo Falini, Keisuke Ito, Maria Paola Martelli, and Hugues de The

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SMN protein is required throughout life to prevent spinal muscular atrophy disease progression., Xin Zhao, Zhihua Feng, Nicole Risher, Anna Mollin, Josephine Sheedy, Karen K Y Ling, Jana Narasimhan, Amal Dakka, John D Baird, Hasane Ratni, Cathleen Lutz, Karen Chen, Nikolai Naryshkin, Chien-Ping Ko, Ellen Welch, Friedrich Metzger, and Marla Weetall