Type 2 Diabetes Associated Genetic Variants Regulate Chromatin Accessibility in Human Islets.
Diabetes 2018 Sep 4 [epub ahead of print]
Doug Coleman research Fund at The Jackson Laboratory, DK092251, ADA Pathway to Stop Diabetes Accelerator Award 1-18-ACE-15
Type 2 Diabetes (T2D) is a complex disorder in which both genetic and environmental risk factors contribute to islet dysfunction and failure. Genome-wide association studies (GWAS) have linked single nucleotide polymorphisms (SNPs), most of which are noncoding, in >200 loci to islet dysfunction and T2D. Identification of the putative causal variants, their target genes, and whether they lead to gain- or loss-of-function remains challenging. Here, we profiled chromatin accessibility in pancreatic islet samples from 19 genotyped individuals and identified 2949 SNPs associated with
Khetan, Shubham; Kursawe, Romy; Youn, Ahrim; Lawlor, Nathan; Jillette, Alexandria; Marquez, Eladio J; Ucar, Duygu; and Stitzel, Michael L., "Type 2 Diabetes Associated Genetic Variants Regulate Chromatin Accessibility in Human Islets." (2018). Faculty Research Ahead of Print. 103.