2-deoxy D-glucose treatment does not elicit a hair growth response in alopecia areata.

John P Sundberg, The Jackson Laboratory
Kathleen A Silva, The Jackson Laboratory
Victoria E. Kennedy, The Jackson Laboratory
John J Wilson, The Jackson Laboratory
Nicholas E Gott, The Jackson Laboratory
Beth A. Sundberg, The Jackson Laboratory
Derry C. Roopenian, The Jackson Laboratory

The authors thank Zoe Reifsnyder for assistance with the figures.


2-deoxy D-glucose (2DG) was tested for efficacy in treating alopecia areata using the C3H/HeJ skin graft model. 2DG has proven to be efficacious in treatment of various mouse models of autoimmunity with minimal serious side effects noted. This agent has been shown to normalize abnormally activated T-cell populations while also preventing cell surface expression of NKG2D; key factors defining alopecia areata disease progression. Daily oral ingestion of 2DG via drinking water to mice with patchy or diffuse alopecia areata for 16 weeks failed to prevent expansion of alopecia or cause regrowth of hair in treated mice. Histologically there were no differences between treated and control groups. These results indicate that, while 2DG is effective for some autoimmune diseases, it was not efficacious for the cell mediated autoimmune mouse disease, alopecia areata. This article is protected by copyright. All rights reserved.