Deficiency of complement component C1Q prevents cerebrovascular damage and white matter loss in a mouse model of chronic obesity.

Leah C. Graham, The Jackson Laboratory
Heidi Kocalis, The Jackson Laboratory
Ileana Soto
Gareth R Howell, The Jackson Laboratory


Age-related cognitive decline and many dementias involve complex interactions of both genetic and environmental risk factors. Recent evidence has demonstrated a strong association of obesity with the development of dementia. Furthermore, white matter damage is found in obese subjects and mouse models of obesity. Here, we found that components of the complement cascade, including C1QA and C3 are increased in the brain of western diet (WD)-fed obese mice, particularly in white matter regions. To functionally test the role of the complement cascade in obesity induced brain pathology, female and male mice deficient in complement component 1qa (C1QA), an essential molecule in the activation of the classical pathway of the complement cascade, were fed a WD and compared to WD-fed WT mice, and to