Targeting Metabolism to Reverse T-cell Exhaustion in Chronic Viral Infections.

John D Sears
Kevin J Waldron
Jian Wei, The Jackson Laboratory
Chih-Hao Chang


CD8 T-cells are an essential component of immune response to viral infections; however, in certain instances, such as chronic infections, they can reach an exhausted state, where T-cells loose glycolytic activity together with cytotoxic capacity. Recent research has indicated that correcting this dysfunctional metabolic state could be key to reversing exhaustion and allowing for proper clearance of chronic viral infections. Here, we review current knowledge about T-cell exhaustion during infection and discuss strategies targeting metabolism that hold promise for its reversal.