Title

Targeting Metabolism to Reverse T-cell Exhaustion in Chronic Viral Infections.

Document Type

Article

Publication Date

7-18-2020

Keywords

JMG

JAX Source

Immunology 2020 Jul 18 [Online ahead of print]

PMID

32681647

DOI

https://doi.org/10.1111/imm.13238

Abstract

CD8 T-cells are an essential component of immune response to viral infections; however, in certain instances, such as chronic infections, they can reach an exhausted state, where T-cells loose glycolytic activity together with cytotoxic capacity. Recent research has indicated that correcting this dysfunctional metabolic state could be key to reversing exhaustion and allowing for proper clearance of chronic viral infections. Here, we review current knowledge about T-cell exhaustion during infection and discuss strategies targeting metabolism that hold promise for its reversal.

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