Macrophages in dermatology: pathogenic roles and targeted therapeutics.
Arch Dermatol Res 2021 Feb 28 [Online ahead of print]
The field of macrophage biology is rapidly growing. Recent studies have shifted focus from classic wound healing roles to newly identified roles in dermatologic pathology. These studies have identified pathogenic roles of macrophages in relatively common conditions, such as psoriasis, skin cancer, and cutaneous T-cell lymphoma. Selective depletion of these cells or their associated cytokines leads to improved clinical outcome. Herein, we review recent animal and human studies that have elucidated novel pathogenic roles of macrophages in conditions frequently encountered by dermatologists and discuss clinically relevant macrophage-targeted therapies.
Kuraitis, Drew; Rosenthal, Nadia; Boh, Erin; and McBurney, Elizabeth, "Macrophages in dermatology: pathogenic roles and targeted therapeutics." (2021). Faculty Research Ahead of Print. 268.