Integration of evidence across human and model organism studies: A meeting report.

Rohan H C Palmer
Emma C Johnson
Hyejung Won
Renato Polimanti
Manav Kapoor
Apurva Chitre
Molly A. Bogue, The Jackson Laboratory
Chelsie E Benca-Bachman
Clarissa C Parker
Anurag Verma
Timothy Reynolds
Jason Ernst
Michael Bray
Soo Bin Kwon
Dongbing Lai
Bryan C Quach
Nathan C Gaddis
Laura Saba
Hao Chen
Michael Hawrylycz
Shan Zhang
Yuan Zhou
Spencer Mahaffey
Christian Fischer
Sandra Sanchez-Roige
Anita Bandrowski
Qing Lu
Li Shen
Vivek M. Philip, The Jackson Laboratory
Joel Gelernter
Laura J Bierut
Dana B Hancock
Howard J Edenberg
Eric O Johnson
Eric J Nestler
Peter B Barr
Pjotr Prins
Desmond J Smith
Schahram Akbarian
Thorgeir Thorgeirsson
David O Walton, The Jackson Laboratory
Erich Baker
Daniel Jacobson
Abraham A Palmer
Michael Miles
Elissa J Chesler, The Jackson Laboratory
Jake Emerson, The Jackson Laboratory
Arpana Agrawal
Maryann Martone
Robert W Williams


The National Institute on Drug Abuse and Joint Institute for Biological Sciences at the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of scientists with expertise in substance use disorders (SUDs), computational biology, and FAIR (Findability, Accessibility, Interoperability, and Reusability) data sharing. The meeting's objective was to discuss and evaluate better strategies to integrate genetic, epigenetic, and 'omics data across human and model organisms to achieve deeper mechanistic insight into SUDs. Specific topics were to (a) evaluate the current state of substance use genetics and genomics research and fundamental gaps, (b) identify opportunities and challenges of integration and sharing across species and data types, (c) identify current tools and resources for integration of genetic, epigenetic, and phenotypic data, (d) discuss steps and impediment related to data integration, and (e) outline future steps to support more effective collaboration-particularly between animal model research communities and human genetics and clinical research teams. This review summarizes key facets of this catalytic discussion with a focus on new opportunities and gaps in resources and knowledge on SUDs.