Title

Inactive rhomboid proteins RHBDF1 and RHBDF2 (iRhoms): a decade of research in murine models.

Document Type

Article

Publication Date

9-3-2021

Publication Title

Mammalian genome : official journal of the International Mammalian Genome Society

Keywords

JMG

JAX Source

Mamm Genome 2021 Sep 3 [Online ahead of print]

ISSN

1432-1777

PMID

34477920

DOI

https://doi.org/10.1007/s00335-021-09910-3

Abstract

Rhomboid proteases, first discovered in Drosophila, are intramembrane serine proteases. Members of the rhomboid protein family that are catalytically deficient are known as inactive rhomboids (iRhoms). iRhoms have been implicated in wound healing, cancer, and neurological disorders such as Alzheimer's and Parkinson's diseases, inflammation, and skin diseases. The past decade of mouse research has shed new light on two key protein domains of iRhoms-the cytosolic N-terminal domain and the transmembrane dormant peptidase domain-suggesting new ways to target multiple intracellular signaling pathways. This review focuses on recent advances in uncovering the unique functions of iRhom protein domains in normal growth and development, growth factor signaling, and inflammation, with a perspective on future therapeutic opportunities.

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