Glioma Through the Looking GLASS: Molecular Evolution of Diffuse Gliomas and the Glioma Longitudinal AnalySiS Consortium.

Kenneth Aldape
Samirkumar B Amin
David M Ashley
Jill S Barnholtz-Sloan
Amanda J Bates
Rameen Beroukhim
Christoph Bock
Daniel J Brat
Elizabeth B Claus
Joseph F Costello
John F de Groot
Gaetano Finocchiaro
Pim J French
Hui K Gan
Brent Griffith
Christel C Herold-Mende
Craig Horbinski
Antonio Iavarone
Steven N Kalkanis
Konstantina Karabatsou
Hoon Kim, The Jackson Laboratory
Mathilde C M Kouwenhoven
Kerrie L McDonald
Hrvoje Miletic
Do-Hyun Nam
Ho Keung Ng
Simone P Niclou
Houtan Noushmehr
Ryan Ormond
Laila M Poisson
Guido Reifenberger
Federico Roncaroli
Jason K Sa
Peter A E Sillevis Smitt
Marion Smits
Camila F Souza
Ghazaleh Tabatabai
Erwin G Van Meir
Roel G W Verhaak, The Jackson Laboratory
Colin Watts
Pieter Wesseling
Adelheid Woehrer
W K Alfred Yung
Christine Jungk
Ann-Christin Hau
Eric van Dyck
Bart A Westerman
Julia Yin
Olajide Abiola
Nikolaj Zeps
Sean Grimmond
Michael Buckland
Mustafa Khasraw
Erik P Sulman
Andrea M Muscat
Lucy Stead
The GLASS Consortium

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Adult diffuse gliomas are a diverse group of brain neoplasms that inflict a high emotional toll on patients and their families. The Cancer Genome Atlas (TCGA) and similar projects have provided a comprehensive understanding of the somatic alterations and molecular subtypes of glioma at diagnosis. However, gliomas undergo significant cellular and molecular evolution during disease progression. We review the current knowledge on the genomic and epigenetic abnormalities in primary tumors and after disease recurrence, highlight the gaps in the literature, and elaborate on the need for a new multi-institutional effort to bridge these knowledge gaps and how the Glioma Longitudinal AnalySiS Consortium (GLASS) aims to systemically catalog the longitudinal changes in gliomas. The GLASS initiative will provide essential insights into the evolution of glioma toward a lethal phenotype, with the potential to reveal targetable vulnerabilities, and ultimately, improved outcomes for a patient population in need. Neuro Oncol 2018 Feb 8 [Epub ahead of print]