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Submissions from 2018

A Computational analysis of cardiac aging using mRNA and protein expression data., Daniel Alfonsetti

Studying the effects of genetic variation on the aminoacyl-tRNA charging pathway using the Diversity Outbred mouse population, Benjamin Allan-Rahill

An Algorithm to Quantitatively Predict Feature-Based Equivalence Between Mouse Inbred Strain Genomes, Rex Asabor

Enhancing Lymph Node Structure in Humanized Mice, Ana Castaner

Transcription factors, their targets, and their role in breast cancer, Jessica Creelman

Understanding the Role of Fibroblasts post-Myocardial Infarction, Maureen Ekwebelem

Inflammasome as an Inflammatory Response to Ocular Hypertension, Annabelle Feist

Characterizing Motor Phenotypes of the Spontaneous Mutant NM5084, Jacqueline Garcia

Development of Parasympathetic Innervation in Aqueous Humor Drainage Structures, Madhumithaq Gautham

Exogenous expression of Scgblcl in understanding its role in cardiac function, Kevin Guerrero

Investigation of the Influence of Nudtl 9 and Dpp 7 Genes on Alzheimer's Disease Progression, Brianna Gurdon

The Effects of AlCF Knock Out on Stressed Mouse Kidneys, Bailey Hixon

Investigating the effects of APOE-£4 on angiogenesis and blood brain barrier integrity in early stages of cerebrovascular development, Larisa Kavetsky

Conservation of Human GWAS Variants in the Mouse Genome, Connor Kean

Rapid Modeling of Developmental Disorders Using CRISPR/ Cas9, Ali Ladha

Pharmacological and Behavioral Characterization of the Reward Pathway in Diverse Mice, Avery Lopez

Stromal regulation of neutrophils during lung metastasis of breast cancer, Sarah Marsden

Identifying the Cause of Decreased Urine pH of Mice on A Caloric Restriction., James Mejia

Identification of Candidate miRNAs as Therapeutic Targets and Biomarkers for Lung Cancer through Differential Expression Analysis, Antonio Mendoza

Framework to Assess Optimal Sequencing Depth Involving Long Noncoding RNAs, Bajram Metjahic

Deciphering Quantitative Phenotypes in Complex Diseases using Gene Co-Expression Modules, Nikhil Milind

Determining the Molecular Mechanisms of Type 1 Diabetes Resistance in Nfkbid Transgenic Non-Obese Diabetic Mice, Anna Quinlan

The Effects of a High-Fat Diet on State-Dependent Activation of the Bed Nucleus of the Stria Terminalis, Katherinne Rabanal

Modeling the Genetic Regulatory Network of Epithelial- Mesenchymal Transition, Dan Ramirez

Developing a Pipeline for Integrating Large Datasets to select candidate Late Onset Alzhei1ner's Disease (LOAD) genes, Sarah Shapley

The Role of STK35 in Germ Cell Development and Fertility, Bailey Shevenell

Identifying genetic interactions related to diabetes using phenotype, Gabriella E. Tenoria

Cell Cycle Profile of Spermatogonial Stem Cells, Diego Trujillo

Lymphocyte Proliferation in response to Cardiomyosin ex vivo, Elias Tzor-Pacheco

Glycine Supplementation in a Mouse Model of Charcot Marie Tooth Type 2D, Kamari Weaver

The Role of TIMP3 Mutation on the Development of Age-Related Macular Degeneration, Nicole Wilkinson

Submissions from 2017

Predicting cancer drug targets using genetic networks., Madelyn Adams

Drivers of pancreatic islet composition., Sadie Allen

Evaluation of concordance of variant to phenotype associations in mouse and human., Cassandra Alvarado

Characterizing sex ratio distortion in the Collaborative Cross., Francesca Barradale

Evaluating machine learning approaches for deciding relevance of ArrayExpress experiments for the Gene Expression Database., Yasmine Boukataya

A reporter system for template bias of meiotic repair in mammals., Emily Bramel

Role of PRDM9 KRAB domain in H3K4 trimethylation at hotspot loci., Naomi Bronkema

Machine learning in the observation of behavioral phenotypes., Gabrielle Cohn

A new GARS mutation, S625L, sensitizes peripheral neurons to degeneration., Donson Cook-Gallardo

Sympathetic innervation of the developing aqueous humor drainage structures., Haelynn Gim

Understanding chemotherapeutic-gene relationships through cross-species analysis., Akeena Harper

Modulation of immune and stromal cells by cancer immunotherapy and chemotherapy in mice., Kevin Hayes

Identification of non-histone protein targets of KMT5A in hematopoietic cells., Teniola Idowu

Genetic drivers of insulin homeostasis., Takanao Ishimura

Mechanistic insights into liposarcoma progression., Ellen Kendall

Identifying addiction related genes through operant sensation seeking in a BXD recombinant inbred panel., Padam Kumar

Understanding the relationship between neuroinflammatory cells and AD-related symptoms through systems genetics., Michelle Kung

Evaluating the therapeutic effect of 2-Deoxy-D-glucose on various cancer models., Nathan Labrie

Characterization of strain specific cardiac macrophage-trophic microenvironments., Kelsey Letson

Examining the role of Dyrkl a in the development and function of inhibitory neurons., Rachel V. Levy

Investigating the role of Rab34 in regulating Hedgehog signaling pathway activity., Amelia Meles

Unbiased profiling of the origin and function of cardiac interstitial cells, Kaesi Morelli

Using gene network analysis to identify novel candidate genes for Congenital Diaphragmatic Hernia (CDH)., Taylar J. Mouton

The genetic mechanism driving risk taking phenotype in BXD recombinant inbred panel., Sartre K. Ndebaneza

Is RNA editing involved in the full recovery of kidneys in Black Bears after hibernation., Selena Neptune-Bear

Research in Action: effectively communicating our translational impact on the JAX.org public website., Grace Niewijk

Assessing Alzheimer's disease phenotypes in a type 2 diabetic mouse model., Bansri Patel

Identifying genetic variation with diet and sex-dependent effects in diversity outbred mice., Douglas Perkins

Modeling the differentiation of induced pluripotent stem cells using single cell RNA sequencing data, Tossapol Pholcharee

Using a HeLa cell filopodia assay to investigate binding interactions of inner ear proteins crucial for hair cell development, Kate Romero

Spermatogonial stem cell self-renewal in the mouse, Danielle Smith

The selection of specific auto reactive T cell populations in diabetes and the effects of Nfkbid on the selection of specific T cell populations., Isabel Stewart

Chracterization of the effect of the Mnm(c) modifying allele on a new, CRISPR-based mouse model of SMARD1, Alex Thele

The effects of diet induced changes of Kir4.1 function in astrocytes and the modulation of homeostatic mechanisms of the regulation of food intake., Violet Witchel

Submissions from 2016

Comparative genomics to determine the genotype responsible for a bacillus subtilis mutant phenotype., Amber Acquaye

Analysis of autoreactive type one diabetes contributory CD8 T-cell frequencies in Nfkbid deficient NOD mice., Jennifer Allocco

Determination of the mutation responsible for tachycardia in ENU mutant strain HLB468., Emma Anderson

The effects of high-fat diets with varied carbohydrate content on the development of diabetes in obese mouse models., Emma Anderson

Determining the genetic framework of hereditary deafness using bioinformatics., Alina K. Andrews

Communicating science at The Jackson Laboratory, Tamsyn Brann

Application of the metabolic inhibitor 2-Deoxy-D-Glucose to treat autoimmune disease in mice., Rachel Burke

From function to dysfunction: gene ontology and cancer., Yoojin Cha

Modifiers of healthy aging: evaluating the effect of diet and physical inactivity on age-dependent dysfunction of the neurovascular system., Yoona Chun

Methyltransferase activities of recombination initiator PRDM9: separating H3K4me3 and H3K36me3 with single amino acid mutations., Max Coffey

Gene mapping of glaucoma related phenotypes in a forward genetics ENU screen., Sherley Collado-Justiniano

What can the genomics of normal development tell us about disease?, Raphael B. Espinoza

Examining expression of Scgb1c1 in developing and adult murine hearts., Adam Fasman

Tracking spontaneous hair cell regeneration in wildtype mice., Michaela Flonard

Testing the paradigm: cancer gene sets and the hallmarks of cancer., Jesus Roberto Franco

Shedding light on microbial dark matter: reference-based species identification in microbiomes., Nicole Gay

Functional interrogation of human T cell co-stimulatory molecules., Jordana Graveley

Innovating high school genomic education with hands-on and classroom teaching methods., Ashley Greaves

The role of androgen receptor in meiotic progress of male germ cells., Nadia V. Harerimana

Characterization of Crichton mutation leading to age-dependent, behavioral phenotypes., Molly Herman

Establishing a role for the kinesin-8 superfamily member Kif18a during cell migration., Ashley Hudson

Elucidating retinal transcripts correlated with changes in the aging brain of an Alzheimer's mouse model., Julia Huesa

Determining the relationship between spermatogonial stem cells and blood vessels in mouse testis., Yuzhao Hu

Varying non-synonymous/synonymous rate ratios (dN/dS) in TCGA data points to prevalence of Darwinian tumor evolution, Alexander Iyabor Jr.

Tandem duplications affect gene integrity/expression in triple negative breast cancer., Tyler Jackson

Lethality in hspn mutant mice., Se Rin (Julie) Kim

The relationship between the adaptive immune system and aging., Samuel Elliot Krause

Discovering the role of pathogenic BRCA1 mutations in tandem duplicator phenotype development., Conner Lajoie

Preserving fertility in the face of oncotherapy: investigating the mechanisms responsible for DNA repair in immature oocytes and implications for fertoprotective treatment., Haleigh Larson

Manipulating beta cell regulatory circuitry using CRISPR/Cas9 epigenome editing., Rujia Lian

Heightened human red blood cell survival in genetically and chemically engineered next generation NSG mice., Cedric Lozano

Modulation of the adaptive immune system by cardiac fibroblasts., Maddie Mara

Analysis of the expression pattern of the Egr2-cre driver in the mouse brain during postnatal development., Kiersten Marr

Investigating the effects of sodium channel dysfunction on chemotherapy induced peripheral neuropathy., Carla Martinez

Evaluating shared system-level phenotype annotations as an indicator of the strength of mouse models for human diseases., Natachi Mez