The Summer Student Program began in 1924 when University of Maine President C.C. Little (our founder) brought six undergraduates to Mount Desert Island for a summer of biological field studies. The Summer Student Program officially became a part of the Jackson Memorial Laboratory's operation in 1931.

Students participate in an ongoing research program with the support of an experienced scientific mentor. They develop an independent project, implement their plan, analyze the data, and report the results. At the end of the summer, they present their findings to researchers, other students, and parents.


Submissions from 2023

Enhancing Deep Learning Model Evaluation via Attention Consistency Analysis in Spatial Transcriptomics Data, Dylan Agyemang

Development of a human iPSC tool kit containing the CRISPR/CAS based Castilio system to test complex genetic circuits in cell differentiation, Annika Bai

The impact of the Y chromosome on the reproductive fitness of male wild-derived mice, Keona Banks

An approach to promoting survival of human microglia in humanized mouse models of Alzheimer's Disease, Lauren Baptiste

IL-6 Monoclonal Antibody Elsilimomab Inhibits Bone Marrow Stromal Cell Senescence Induced by Dnmt3a-Mutant Clonal Hematopoiesis, David Bernal

Effect of hair cell orientation on mechanotransduction response in the vestibular system, Kayla Bright

Selective ablation of the ELF3 transcription factor and its effects on trophoblast stem cell, syncytiotrophoblast, and primitive syncytium differentiation, Carla D'Amato

Identifying the Genetic Basis of Immune Checkpoint Inhibitor Induced Type 1 Diabetes, Tobias Emge

Contrasting Osteosarcoma and Epithelial Breast Cancer Immune Regulation in Murine Cell Lines, Juliana Fenimore

Comparing Ovarian Reserve Damage Response to Different Sources of Radiation Exposure, Paris Guerrero

Modeling hyperopia in Prss56glcr4 mice: Molecular comparativ analysis with Mfrprd6 and QTL mapping of axial length alterations, Jessica Guzman

Automated Assessment of Feeding Behaviors in Mice Using Machine Vision, Cayson Hamilton

Investigating a Genetically Diverse Mouse Model for Vasculitis, Emma Hendrix

Elucidating Gli3 and Hand2 interactions in the developing mandible, Aria Hossain

Characterization of the Pulmonary Phenotype of a Zfhx4 Mutant Mouse Model During Embryonic Development, Sara Hunstad

Using Modified Bacterial Artificial Chromosomes to Develop Transgenic Mouse Models Containing Human Genes with Disease Causing Mutations, Srilekha Kadimi

Identifying Transcriptomic Signatures to Mediate Causal Effect of Genotype on Alzheimer's Disease, Simran Kaur

Neoteny in Mice: The effects of PDGFRα+ cell depletion during postnatal growth, Raheem Khadour

Characterizing retinal vascular development in New Zealand Obese mice, Julia Klein

Identification of structural variants leading to non-reference gene structure, Grace Koo

Unraveling the Role of Glycolysis-Derived Pyruvate in Modulation of TIM-3 Expression in Cancer, Chloe Ledford

Characterizing de novo variants in the CRISPR-Cas9 edited KOLF2.2J iPSC cell line, Alyssa Lima

Cell Cycle Changes Following TPHP Exposure of Induced Pluripotent Stem Cells, Lacie Low

The Milky Way Project: Multi-omic Clocks of Biological Age and Rates of Aging, Matthew Luchs

Characterizing neuromuscular degeneration in mouse models of rare neuromuscular disease through neurogenic and myogenic attributes, Aria Ma

The Impact of Zbtb7a and Zbtb7b Loss in Acute Myeloid Leukemia Drug Resistance, Meryl McKenna

Identifying core and accessory essential genes of genetically diverse Staphylococcus epidermidis strains with genome-wide CRISPRi screens, Sierra Mellor

The Effect of Genetic Background on Charcot-Marie-Tooth Histopathology in Mice, Lily Moy

Variant Caller Performance on Diverse Strains: Exploring the significance of the reference genome on caller performance, Aleisha Roberts

The role of EPASI, an oxygen-sensing transcription facor, in trophoblast differentiation, Braeden Rose

Cortex-wide In-vivo Two-photon Calcium Imaging Analysis of Mice During Skilled Reaching, Andrea Ruiz D'Argence

Generation of transgenic pluripotent stem cells to overexpress neuronal survival genes against stroke using CRISPR-activation technology, Pilar Saavedra-Weis

Targeting gene fusions as a therapeutic approach in pediatric cancers, Elisa Saint-Denis

Characterization of Glycosylation in a Cancer Model, Elaine Schumacher

Growth kinetics and treatment of pharyngeal carcinoma in immunodeficient mice, Leah Spade

Assessing GPX4 as a Blood-Based Biomarker via a LLM-engaged Gene Prioritization and Characterization Workflow, Bishesh Subba

Plasticity Requirements in IL-to-BLA Circuitry During Extinction Learning, Allison Velie

Exploring Adipose Cellular Heterogeneity in Mice, Gabriella von Dohlen

Modeling the dynamics of BRCA1 promoter methylation relevant to triple-negative breast cancer, Anthony Woodruff

Submissions from 2022

Chromatin Looping Differences between 129S and CAST Mice Regulate Transcriptional Variation, Beatriz Alvarez

Immunomodulatory metabolite production by commensal microbiome bacteria, Christian Badawi

The Effects of Genetic Variation on Acute Myeloid Leukemia Growth in Mice, Dan Bernstein

Investigating Loss of Methylation at the BRCA1 Promoter as a Mechanism of Chemoresistance, Benjamin C. Brim

Quantifying the spatial relationship between PORCN and JAG1 in the Mouse Cochlea, Emily Burt

Effects of Microglia Depletion on Dendritic Spine Architecture in Genetically Distinct Alzheimer's Disease Mouse Models, Harry Chen

Role of srGAP3 protein stability in mediating voluntary cocaine abuse in Gridlock'd mutant mice, Elaina Cote

Investigating the endometrial microenvironment via characterization of progenitor-like epithelial cells and fibroblastic response to trophectoderm secretions, Colt Crain

Using Machine-Vision to Quantify Mouse Behavior, Joseph DuPree

Exploring NKT cell and Perforin-mediated regulation of digit tip regeneration in both male and female adult mice, Nina Greeley

Visual Prediction of Mouse Mass using Machine Learning, Malachy Guzman

Morphological analysis of cutaneous T-cell lymphoma unaging using attention-based deep learning, Amaris Huang

Analyzing C12orf65 (MTRFR) Expression in Mutant Mouse Models, Jupiter Kalinowski

Essential function of Slmap in embryonic development and skeletal differentiation, Tess Kelly

Individual differences in cognitive resilience to AD are not explained by variation in neurogenesis in the AD-BXDs, Emily Kim

Comparative effects of acute inflammatory challenge on hematopoietic stem cell differentiation in mouse models of clonal hematopoiesis., Hanna Kodama

The effect of the Arg1956Trp mutation in the IQ3 domain of MYO15A on stereocilia formation and hearing loss, Lilly Krupp

Profiling the transposable element landscape in a new wild mouse resource, Sirohi Kumar

The Expression of ZFHX4 Protein in Developing Mouse Lungs and Lung Adenocarcinoma, Tina Li

Transfer learning of a multitask deep neural network to predict enhancer activity of regulatory variants in the HCT116 cell-line, Frank Liu

Developing and Using an R Package To Identify Causative Variations Driving Gene eQTL, Bryant Luna-Ramos

Molecular Approaches to Increase Stroke Resiliency Using Human Pluripotent Stem Cell- Derived Neurons, Elise MacDonald

Investigation of Metabolic Changes for Early Detection of Alzheimer's Disease, Megan Sherally Mathews

Bxb1-Integrase and Modified Bacterial Artificial Chromosomes as a Tool for Site-Specific Transgenesis of Large Donor DNA into Mouse Models, Thomas Mehaffey

Metabolic Control of T follicular helper cell polarization, Anthony Mendoza

Investigating the role of potential PRDM9 interactors FUS and DEK in recombination hotspot activation., Adel Misherghi

Using the Collaborative Cross to identify putative gamete compatibility genes, Clare Mulcahy

Investigating the Infralimbic-Amygdala Circuit During Fear Extinction Learning, Grace O'Brien

Assessing the Potential Relevance of TMOD1 as a Blood Transcriptional Biomarker, Fuadur Omi

Gene fusion dependence in acute myeloid leukemia Ewing sarcoma, and ependymoma cell lines, Aisha Pasha

Efficacy of a High Fat Diet and L-NAME Combinatory Mouse Model for Heart Failure With Preserved Ejection Fraction, Maggie Peng

Utilizing CRISPR technologies to probe Staphylococcus epidermidis' role in the human skin microbiome, Destiny Porter

Characterization of Spontaneous Sugar Modifications of Proteins, Lily Sabol

Role of Flial Cells in the Arcuate Nucleus of the Hypothalamus in High-Fat Diet Consuming Mice, Hunter Samuel

Investigating the Oocyte DNA Damage Response after Radiation Exposure, Michelle Seeler

Assessment of axonal regeneration in Gjb1/CMT1X mouse model, Alsu Shagieva

Identifying signatures of mutational mechanisms for tandem duplications found in breast cancers, Leila Shepard

The role of Oit3 in embryonic development, Lenka Slamova

Advancing Metabolic Flux Analysis in the Single-Cell Era, Maggi Smart

Single-nucleus Transcriptome Profiling of Cancer-associated Fibroblasts in Glioma, Andreas Stephanou

Weighted learning for long-read DNA sequencing consensus methylation detection, Emma Wade

Optimizing the morphological characterization of single hippocampal neurons using Patch-seq, Annie Williams

The Effects of Heterochromatin Formation on 3-D Genome Contacts in Mouse Embryonic Stem Cells, Brooke Wilson

Submissions from 2021

Employing ChIP-Seq to Identify Novel Genes and Pathways for Congenital Diaphragmatic Hernia (CDH), Syed Ali

Comparison of eQTL Identification when using Single-end or Paired- end RNA-sequencing Data, Sam Ardery

Exploration of the Patient-Derived Xenografts at the Jackson Laboratory, Kara Barnao

Analysis of the interaction of genetic background with DYRK1a inhibition on the proliferation and differentiation of mouse embryonic stem cell-derived Neural Precursor Cell, Nicole Da Costa

Are Genetic Effects on Gene Expression Correlated Within TAD Boundaries?, Alexander Daines

Engineering induced pluripotent stem cells to capture critical mechanisms of dendritic cells activation, Richard Fu

Data Annotation Module for Frictionless Data, Naomie Gao

V225G Mutation Increases Stability of KPNA3 Thereby Contributing to an Age-Dependent Hyperactive Phenotype in C57BL/6J Mice, Ryan Guardado

Evaluating the Role of RFX3 in Kidney Function and Cilial Development in an Alport Syndrome Mouse Model, Isabel Huesa

Characterizing TNF-alpha levels in the context of Dnmt3a-mutant bone marrow, Brandon James

Modifiers of Charcot-Marie-Tooth Disease Type 1A Neuropathy in the Sox10/Egr2 Networ, Leeza Kopaeva

The Effect of Allelic Variation on Genetic Recombination and Oocyte Quality, Priya Kosana

Establishing in vitro mES-RPE cells bearing S28C TIMP3 mutation toidentify mouse models for Age Related Macular Degeneration., English Laserna

Determining the Role of the ELF3 gene in trophoblast cell differentiation. The Jacksons Laboratory Summer Student Program, Abraham Lopez

Comparing Gene Sets by Comparing Gene Enrichmen, Irissa Machetta

In vitro validation of inhibitors targeting TCF-4 and beta catenin interaction in WNT-activated tumors, Cynthia Martucci

Profiling Genomic Diversity in a New Wild Mouse Strain Resource, Gabriel McMillen

Longitudinal investigation of the gut microbiome in a Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) cohort, Stefanie Moncayo