The regulation of heat shock factor 1 by Akt and phosphatidylinositol 3-kinase.


Terry Chen

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In: Summer Student Reports, 2011, Jackson Laboratory


The goal of the research is to determine if PI3K signaling pathway regulates the HSF-mediated heat shock response, and whether or not this process is mediated by Akt (a serine/threonine protein kinase that plays a key role in multiple cellular processes such as glucose metabolism). In the long term, we are investigating the potential for the therapeutic applications of targeting HSF1 and its mediated stress response in human cancers. My role in the process will be to conduct the Chromatin Immunoprecipitation (ChIP) to provide in vivo evidence that PI3K regulates HSF1’s DNA binding activity.


UCLA, Los Angeles, CA

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