What can the genomics of normal development tell us about disease?

Document Type


Publication Date

Summer 2016

JAX Location

In: Student Reports, Summer 2016, Jackson Laboratory


The purpose of this study is to investigate the connection between development and disease by comparing genome-wide gene expression during normal lung development to differentially expressed genes in lung cancer and other respiratory diseases. Our study builds on previous genomic studies linking cancer and normal development. Expanding on these works, we will revalidate previous findings, explore if choice of mouse strain influences the patterns observed previously, and determine if normal development provides a framework for understanding the genomic basis of diseases other than cancer.

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