Characterizing sex ratio distortion in the Collaborative Cross.

Document Type


Publication Date

Summer 2017

JAX Location

In: Student Reports, Summer 2017, Jackson Laboratory


A deviation from the 1:1 sex ratio of males to females is a visible consequence of genetic conflict. In this project, we used statistical analysis of breeding records, fluorescent imaging of sperm, and analyses of whole genome sequences to study the prevalence and mechanisms of sex ratio distortion in Collaborative Cross (CC) mice. Six CC lines demonstrate consistent distortion at both the University of North Carolina (UNC) and the Jackson Laboratory (JAX). Of these strains, two harbor copy number variation of Sly, Slx, and Slx11 consistent with one known mode of sex ration distortion in mice, suggesting the existence of multiple distortion mechanisms.

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