Characterizing sex ratio distortion in the Collaborative Cross.
Document Type
Article
Publication Date
Summer 2017
JAX Location
In: Student Reports, Summer 2017, Jackson Laboratory
Sponsor
Dr. Bethany Dumont
Abstract
A deviation from the 1:1 sex ratio of males to females is a visible consequence of genetic conflict. In this project, we used statistical analysis of breeding records, fluorescent imaging of sperm, and analyses of whole genome sequences to study the prevalence and mechanisms of sex ratio distortion in Collaborative Cross (CC) mice. Six CC lines demonstrate consistent distortion at both the University of North Carolina (UNC) and the Jackson Laboratory (JAX). Of these strains, two harbor copy number variation of Sly, Slx, and Slx11 consistent with one known mode of sex ration distortion in mice, suggesting the existence of multiple distortion mechanisms.
Recommended Citation
Barradale, Francesca, "Characterizing sex ratio distortion in the Collaborative Cross." (2017). Summer and Academic Year Student Reports. 2566.
https://mouseion.jax.org/strp/2566