Title

Understanding chemotherapeutic-gene relationships through cross-species analysis.

Authors

Akeena Harper

Document Type

Article

Publication Date

Summer 2017

JAX Location

In: Student Reports, Summer 2017, Jackson Laboratorn

Abstract

The purpose of this study is to observe and compare chemotherapy-related gene sets from humans, rats and mice to understand how chemotherapeutic agents, particularly Cisplatin, interact with genes and the processes to which they contribute. We used Gene Weaver (GW)1, the Comparative Toxicogenomics Database (CTD)2, Gene Ontology (GO)3 and the Visual Annotation Display (VLAD)4 to conduct our research. We found that the unfiltered human cisplatin-interacting gene set is significantly enriched in genes associated with apoptosis, a finding confirmed by cross-species analysis. Filtering for genes that bind Cisplatin showed that the remaining human gene set significantly overlapped gene sets involved in copper transport. Comprehensive literature searches allowed us to further analyze and evaluate our data and conclusions.

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