The genetic mechanism driving risk taking phenotype in BXD recombinant inbred panel.
In: Student Reports, Summer 2017, Jackson Laboratory
Dr. Price Dickson and Dr. Elissa Chesler
Drug addiction is an inherited disease which its genetic mechanism remains unknown. Previous studies have shown that personal trait such as risk-taking is associated with drug addiction in humans. Finding biological mechanisms that drive risk-taking behavior was the challenge that we faced in this study. But using publicly data sets on GeneNetwork, we identified candidate genes which are correlated with risk- taking phenotype in BXD recombinant inbred mouse panel. We used GeneNetwork (www.genenetwork.com) and GeneWeaver (www.geneweaver.com) to perform a comprehensive genetic analysis of the risk-taking phenotype. Using visual cliff data, we assessed a principal component of risk avoidant (PC2). We used GeneNetwork to perform QTL Miner to select and prioritize candidate genes mapped within a significant QTLs. Then we measured the correlation between risk-taking phenotype and genes underlying in midbrain, PFC, NAc. We identified genome-wide significant QTL on chromosome 1 and 15. We discovered 13 non-overlapping genes underlying within chromosome 1 in the brain regions we analyzed including midbrain, nucleus accumbens, and prefrontal cortex. We found a positive correlation between risk-taking phenotype and Gml 0384 gene underlying in midbrain. The data found suggested candidate genes that drive risk-taking behavior in mice. We think Gm 10384 gene plays a key role in driving risk-taking phenotype in BXD recombinant inbred mouse panel.
Ndebaneza, Sartre K., "The genetic mechanism driving risk taking phenotype in BXD recombinant inbred panel." (2017). Summer and Academic Year Student Reports. 2582.