The genetic mechanism driving risk taking phenotype in BXD recombinant inbred panel.

Document Type


Publication Date

Summer 2017

JAX Location

In: Student Reports, Summer 2017, Jackson Laboratory


Drug addiction is an inherited disease which its genetic mechanism remains unknown. Previous studies have shown that personal trait such as risk-taking is associated with drug addiction in humans. Finding biological mechanisms that drive risk-taking behavior was the challenge that we faced in this study. But using publicly data sets on GeneNetwork, we identified candidate genes which are correlated with risk- taking phenotype in BXD recombinant inbred mouse panel. We used GeneNetwork (www.genenetwork.com) and GeneWeaver (www.geneweaver.com) to perform a comprehensive genetic analysis of the risk-taking phenotype. Using visual cliff data, we assessed a principal component of risk avoidant (PC2). We used GeneNetwork to perform QTL Miner to select and prioritize candidate genes mapped within a significant QTLs. Then we measured the correlation between risk-taking phenotype and genes underlying in midbrain, PFC, NAc. We identified genome-wide significant QTL on chromosome 1 and 15. We discovered 13 non-overlapping genes underlying within chromosome 1 in the brain regions we analyzed including midbrain, nucleus accumbens, and prefrontal cortex. We found a positive correlation between risk-taking phenotype and Gml 0384 gene underlying in midbrain. The data found suggested candidate genes that drive risk-taking behavior in mice. We think Gm 10384 gene plays a key role in driving risk-taking phenotype in BXD recombinant inbred mouse panel.

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