Transcription factors, their targets, and their role in breast cancer

Document Type


Publication Date

Summer 2018

JAX Location

In: Student Reports, Summer 2018, The Jackson Laboratory


Transcription factors (TFs) are proteins that bind to DNA, affecting how it is transcribed. Many transcription factors, when mutated, play roles in the formation and progression of cancers. The goal of this project was to see if we could reach a greater understanding of the roles that mutated TFs have in the formation of breast cancers through an analysis of the genes they regulate. To accomplish this, we analyzed the target genes of mutated transcription factors to determine their possible contribution to cancer mechanisms. Our expectation is that a greater understanding of the contribution of mutated transcription factors in breast cancer progression could be helpful in focusing treatment approaches.

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