Transcription factors, their targets, and their role in breast cancer
In: Student Reports, Summer 2018, The Jackson Laboratory
Dr. Judith Blake and Dr. David Hill
Transcription factors (TFs) are proteins that bind to DNA, affecting how it is transcribed. Many transcription factors, when mutated, play roles in the formation and progression of cancers. The goal of this project was to see if we could reach a greater understanding of the roles that mutated TFs have in the formation of breast cancers through an analysis of the genes they regulate. To accomplish this, we analyzed the target genes of mutated transcription factors to determine their possible contribution to cancer mechanisms. Our expectation is that a greater understanding of the contribution of mutated transcription factors in breast cancer progression could be helpful in focusing treatment approaches.
Creelman, Jessica, "Transcription factors, their targets, and their role in breast cancer" (2018). Summer and Academic Year Student Reports. 2602.