Development of Parasympathetic Innervation in Aqueous Humor Drainage Structures

Document Type


Publication Date

Summer 2018

JAX Location

In: Student Reports, Summer 2018, The Jackson Laboratory


Glaucoma is the leading cause of irreversible blindness in the world. Increased IOP is a major risk factor for primary open-angle glaucoma. Most of the resistance to outflow is localized in the Schlemm's Canal (SC), the last barrier to outflow. The purpose of this study is to gain an understanding of the mechanisms involved in regulating intraocular pressure (IOP). The development of parasympathetic innervation in the SC was studied using a special anterior cup whole mounting technique, immunofluorescence, confocal microscopy, and 3D image analysis.

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