Are Genetic Effects on Gene Expression Correlated Within TAD Boundaries?

Document Type


Publication Date

Summer 2021

JAX Location

In: Student Reports, Summer 2021, The Jackson Laboratory


The purpose of this study is to understand the role of topologically associating domains(TADs) in the genetics of gene expression. A TAD is a genomic region within which DNA regulatory regions physically interact with each other more frequently than outside of the region.Data from a genetically diverse population of mice will be utilized to map the correlation between genetic position and genetic effects. The measure of this correlation within TAD boundaries will illustrate the role of TADs in gene expression. From this study we were able to characterize the relationship between TADs, gene expression, and subsequently, allele effect correlation. We found a significant association between TAD boundaries and gene regulation, strongly suggesting confirmation of the hypothesized role of topologically associating domains in gene regulation.

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