Are Genetic Effects on Gene Expression Correlated Within TAD Boundaries?
In: Student Reports, Summer 2021, The Jackson Laboratory
Gregory Carter, Ph.D.
The purpose of this study is to understand the role of topologically associating domains(TADs) in the genetics of gene expression. A TAD is a genomic region within which DNA regulatory regions physically interact with each other more frequently than outside of the region.Data from a genetically diverse population of mice will be utilized to map the correlation between genetic position and genetic effects. The measure of this correlation within TAD boundaries will illustrate the role of TADs in gene expression. From this study we were able to characterize the relationship between TADs, gene expression, and subsequently, allele effect correlation. We found a significant association between TAD boundaries and gene regulation, strongly suggesting confirmation of the hypothesized role of topologically associating domains in gene regulation.
Daines, Alexander, "Are Genetic Effects on Gene Expression Correlated Within TAD Boundaries?" (2021). Summer and Academic Year Student Reports. 2661.