Metabolic regulation of CXCR5 expression in T cells via the kynurenine pathway

Document Type


Publication Date

Summer 2021

JAX Location

In: Student Reports, Summer 2021, The Jackson Laboratory


Adaptive immunity consists of B and T cells that will respond to neoantigens over time by recognizing specific pathogens or tumors. In this study, we are interested in a subset of CD4+ helper T cells, follicular B helper T (Tfh) cells. The Chang Lab recently discovered that a compound called kynurenine, a tryptophan breakdown product, results in increased expression of C-X-C chemokine receptor type 5 (CXCR5) in T cells (unpublished data). This understudied compound in immune cells will help provide implications for how CXCR5, and thus effector T cell function, may be regulated. Through the utilization of in vitro and in vivo methods, we have identified the importance of metabolic regulation of expression of kynurenine-induced CXCR5 expression, and how this kynurenine-CXCR5 expression may contribute to overall T cell function.

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