Effects of Microglia Depletion on Dendritic Spine Architecture in Genetically Distinct Alzheimer's Disease Mouse Models


Harry Chen

Document Type


Publication Date

Summer 2022



JAX Location

In: Student Reports, Summer 2022, The Jackson Laboratory


Alzheimer’s disease (AD) is a common neurodegenerative disease that causes progressive cognitive decline. It is characterized by the accumulation of amyloid-β plaques and tau tangles, which have been linked to synaptic and neuronal loss. Microglia are thought to play an important role in this loss. Previous studies have revealed that genetically diverse mouse strains develop different microglia states. These states may influence how microglia prune hippocampal synapses, which can be measured through dendritic spine density and volume. Here we show that microglia- depleted mice tended to have a higher dendritic spine density in transgenic AD mice and a lower density in wildtype mice. We also show that microglia depleted mice tend to have higher individual and total spine volume regardless of genotype.

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