Investigation of Metabolic Changes for Early Detection of Alzheimer's Disease
In: Student Reports, Summer 2022, The Jackson Laboratory
Greg Carter, Ph.D.
It has previously been determined that there is a direct link between brain metabolism and the build up of amyloid-β peptides consistent with Alzheimer’s Disease (AD). However, there is research to suggest that the changes in metabolism actually contribute to the disease itself. Using R as a data analysis tool, the correlation between the proteomics and both the blood and brain metabolomes of two types of AD mouse models (early and late onset types) were investigated. It was found that there are many metabolites heavily correlated and anticorrelated (correlation coefficient magnitude ≥ 0.5) with cerebral proteins, most notably lysoPC.a.C18 and PC.aaa.C42.6. Lyso.PC.a.C18 in the brain metabolome was found to be positively correlated (r ≥ 0.9) with Clusterin, a hallmark of AD, and PC.aaa.C42.6 were found to be positively correlated (≥0.9) with NDUFS7, another hallmark of AD. The findings of this research affirm a strong link between metabolic changes and proteomic changes associated with AD. PC.aaa.C42 having a strong correlation with AD proteomics yields the possibility that it could be an AD biomarker relevant for disease detection, while the strong cerebral correlations of lysoPC.a.C18 to AD proteomics could give insight into the cause of the disease itself.
Mathews, Megan Sherally, "Investigation of Metabolic Changes for Early Detection of Alzheimer's Disease" (2022). Summer and Academic Year Student Reports. 2705.