Targeting gene fusions as a therapeutic approach in pediatric cancers
In: Student Reports, Summer 2023, The Jackson Laboratory
Nathaliel Jillet, and Ching Lau, Ph.D.
Gene fusions are a recurrent and disease-specific class of somatic alterations common in pediatric cancers, making them an important biomarker for both diagnosis and treatment. Previous work has identified gene fusions involved in a wide variety of pediatric cancer types and begun to develop fusion RNA-targeting therapies. The aim of this project was to optimize the development of fusion-targeting therapeutics by 1) developing an application to easily identify and prioritize fusions to target for therapeutic development, and 2) creating an EWSR1-FLI1 fusion-expressing plasmid to test novel RNA sensors. The developed application highlights recurrent fusions for future RNA sensor design, and an efficient RNA sensor design was identified through testing using EWSR1-FLI1 fusion-expressing plasmid.
Saint-Denis, Elisa, "Targeting gene fusions as a therapeutic approach in pediatric cancers" (2023). Summer and Academic Year Student Reports. 2738.