Most Popular Papers*

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Recurrent inversion polymorphisms in humans associate with genetic instability and genomic disorders.
David Porubsky, Wolfram Höps, Hufsah Ashraf, PingHsun Hsieh, Bernardo Rodriguez-Martin, Feyza Yilmaz, Jana Ebler, Pille Hallast, Flavia Angela Maria Maggiolini, William T Harvey, Barbara Henning, Peter A Audano, David S Gordon, Peter Ebert, Patrick Hasenfeld, Eva Benito, Qihui Zhu, Charles Lee, Francesca Antonacci, Matthias Steinrücken, Christine R Beck, Ashley D Sanders, Tobias Marschall, Evan E Eichler, and Jan O Korbel

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Prophylactic evaluation of verubecestat on disease- and symptom-modifying effects in 5XFAD mice.
Adrian L Oblak, Zackary A Cope, Sara K Quinney, Ravi S Pandey, Carla Biesdorf, Andi R Masters, Kristen D. Onos, Leslie Haynes, Kelly J Keezer, Jill A Meyer, Jonathan S Peters, Scott A Persohn, Amanda A Bedwell, Kierra Eldridge, Rachael Speedy, Gabriela Little, Sean-Paul Williams, Brenda Noarbe, Andre Obenaus, Michael Sasner, Gareth R Howell, Gregory W. Carter, Harriet M. Jackson, Bruce T Lamb, Paul R Territo, and Stacey J Sukoff Rizzo

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Cardiac cellularity is dependent upon biological sex and is regulated by gonadal hormones.
Galen T Squiers, Michael A McLellan, Alexei Ilinykh, Jane Branca, Nadia Rosenthal, and Alexander R Pinto

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Functional elements of the cis-regulatory lincRNA-p21.
Lauren Winkler, Maria Jimenez, Joshua T Zimmer, Adam Williams, Matthew D Simon, and Nadya Dimitrova

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Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19.
Avraham Unterman, Tomokazu S Sumida, Nima Nouri, Xiting Yan, Amy Y Zhao, Victor Gasque, Jonas C Schupp, Hiromitsu Asashima, Yunqing Liu, Carlos Cosme, Wenxuan Deng, Ming Chen, Micha Sam Brickman Raredon, Kenneth B Hoehn, Guilin Wang, Zuoheng Wang, Giuseppe DeIuliis, Neal G Ravindra, Ningshan Li, Christopher Castaldi, Patrick Wong, John Fournier, Santos Bermejo, Lokesh Sharma, Arnau Casanovas-Massana, Chantal B F Vogels, Anne L Wyllie, Nathan D Grubaugh, Anthony Melillo, Hailong Meng, Yan Stein, Maksym Minasyan, Subhasis Mohanty, William E Ruff, Inessa Cohen, Khadir Raddassi, Laura E Niklason, Albert I Ko, Ruth R Montgomery, Shelli F Farhadian, Akiko Iwasaki, Albert C Shaw, David van Dijk, Hongyu Zhao, Steven H Kleinstein, David A Hafler, Naftali Kaminski, and Charles S Dela Cruz

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Three decades of the Human Genome Organization.
Charles Lee, Stylianos E Antonarakis, Ada Hamosh, and John Burn

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Systematic reconstruction of cellular trajectories across mouse embryogenesis.
Chengxiang Qiu, Junyue Cao, Beth K Martin, Tony Li, Ian C Welsh, Sanjay Srivatsan, Xingfan Huang, Diego Calderon, William Stafford Noble, Christine M Disteche, Stephen A. Murray, Malte Spielmann, Cecilia B Moens, Cole Trapnell, and Jay Shendure

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Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer's disease.
Hongtian Stanley Yang, Kristen D. Onos, Kwangbom Choi, Kelly J Keezer, Daniel A Skelly, Gregory W. Carter, and Gareth R Howell

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Transcriptional profiling of macrophages in situ in metastatic melanoma reveals localization-dependent phenotypes and function.
Jan Martinek, Jianan Lin, Kyung In Kim, Victor G Wang, Te-Chia Wu, Michael Chiorazzi, Hannah Boruchov, Ananya Gulati, Shamreethaa Seeniraj, Lili Sun, Florentina Marches, Paul Robson, Anthony Rongvaux, Richard A Flavell, Joshy George, Jeffrey Chuang, Jacques Banchereau, and Karolina Palucka

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