Most Popular Papers*

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Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation.
Shubham Khetan, Susan Kales, Romy Kursawe, Alexandria Jillette, Jacob C Ulirsch, Steven K Reilly, Duygu Ucar, Ryan Tewhey, and Michael L. Stitzel

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A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice.
Jason A. Bubier, Vivek M. Philip, Christopher Quince, James Campbell, Yanjiao Zhou, Tatiana Vishnivetskaya, Suman Duvvuru, Rachel Hageman Blair, Juliet Ndukum, Kevin D Donohue, Carmen M Foster, David J Mellert, George M. Weinstock, Cymbeline T Culiat, Bruce F O'Hara, Anthony V Palumbo, Mircea Podar, and Elissa J Chesler

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Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment.
Hua Sun, Song Cao, R Jay Mashl, Chia-Kuei Mo, Simone Zaccaria, Michael C Wendl, Sherri R Davies, Matthew H Bailey, Tina M Primeau, Jeremy Hoog, Jacqueline L Mudd, Dennis A Dean, Rajesh Patidar, Li Chen, Matthew A Wyczalkowski, Reyka G Jayasinghe, Fernanda Martins Rodrigues, Nadezhda V Terekhanova, Yize Li, Kian-Huat Lim, Andrea Wang-Gillam, Brian A Van Tine, Cynthia X Ma, Rebecca Aft, Katherine C Fuh, Julie K Schwarz, Jose P Zevallos, Sidharth V Puram, John F Dipersio, NCI PDXNet Consortium, Brandi Davis-Dusenbery, Matthew J Ellis, Michael T Lewis, Michael A Davies, Meenhard Herlyn, Bingliang Fang, Jack A Roth, Alana L Welm, Bryan E Welm, Funda Meric-Bernstam, Feng Chen, Ryan C Fields, Shunqiang Li, Ramaswamy Govindan, James H Doroshow, Jeffrey A Moscow, Yvonne A Evrard, Jeffrey Chuang, Benjamin J Raphael, Li Ding, Carol J Bult, and Peter N Robinson

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An effective biomedical document classification scheme in support of biocuration: addressing class imbalance.
Xiangying Jiang, Martin Ringwald, Judith A. Blake, Cecilia Arighi, Gongbo Zhang, and Hagit Shatkay

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Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study.
Adrian L Oblak, Peter B Lin, Kevin P Kotredes, Ravi S Pandey, Dylan Garceau, Harriet M. Jackson, Asli Uyar, Rita O'Rourke, Sarah O'Rourke, Cynthia Ingraham, Daria Bednarczyk, Melisa Belanger, Zackary A Cope, Gabriela J Little, Sean-Paul G Williams, Carl Ash, Adam Bleckert, Tim Ragan, Benjamin A Logsdon, Lara M Mangravite, Stacey J Sukoff Rizzo, Paul R Territo, Gregory W. Carter, Gareth R Howell, Michael Sasner, and Bruce T Lamb

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Ultrastructural visualization of 3D chromatin folding using volume electron microscopy and DNA in situ hybridization.
Paweł Trzaskoma, Błażej Ruszczycki, Byoungkoo Lee, Katarzyna K Pels, Katarzyna Krawczyk, Grzegorz Bokota, Andrzej A Szczepankiewicz, Jesse Aaron, Agnieszka Walczak, Małgorzata A Śliwińska, Adriana Magalska, Michal Kadlof, Artur Wolny, Zofia Parteka, Sebastian Arabasz, Magdalena Kiss-Arabasz, Dariusz Plewczyński, Yijun Ruan, and Grzegorz M Wilczyński

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Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo.
Laura M Vecchio, Patricia Sullivan, Amy R Dunn, Marie Kristel Bermejo, Rong Fu, Shababa T Masoud, Emil Gregersen, Nikhil M Urs, Reza Nazari, Poul Henning Jensen, Amy Ramsey, David S Goldstein, Gary W Miller, and Ali Salahpour

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AMULET: a novel read count-based method for effective multiplet detection from single nucleus ATAC-seq data.
Asa Thibodeau, Alper Eroglu, Christopher S McGinnis, Nathan Lawlor, Djamel Nehar-Belaid, Romy Kursawe, Radu Marches, Daniel N Conrad, George A Kuchel, Zev J Gartner, Jacques Banchereau, Michael L. Stitzel, A Ercument Cicek, and Duygu Ucar

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Association of CNVs with methylation variation.
Xinghua Shi, Saranya Radhakrishnan, Jia Wen, Jin Yun Chen, Junjie Chen, Brianna Ashlyn Lam, Ryan E Mills, Barbara E Stranger, Charles Lee, and Sunita R Setlur

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