Faculty Research 1970 - 1979

Title

A regulatory locus for mouse beta-glucuronidase induction, Gur, controls messenger RNA activity.

Document Type

Article

Publication Date

1979

Keywords

Enzyme-Induction: de, Female, Genes-Regulator, Genes-Structural, Glucuronidase: ge, Heat, Kidney: en, Linkage-(Genetics), Mice, Oocytes: me, RNA-Messenger: ge, SUPPORT-U-S-GOVT-P-H-S, Testosterone, Xenopus

JAX Source

Science 1979 Feb 9; 203(4380):554-6.

Abstract

A regulatory locus in a higher organism has been shown to control a specific messenger RNA activity. The Gur locus in mice regulates the production of kidney beta-glucuronidase messenger RNA activity after induction of the beta-glucuronidase structural gene, Gus, by testosterone. beta-Glucuronidase messenger RNA was assayed by its ability to direct the synthesis of catalytically active murine beta-glucuronidase in Xenopus oocytes.

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