Faculty Research 1970 - 1979

Title

Aryl hydrocarbon hydroxylase inducibility is not altered in bladder cancer patients or their progeny.

Document Type

Article

Publication Date

1979

Keywords

Aged, Aryl-Hydrocarbon-Hydroxylases: bi, ge, Bladder-Neoplasms: en, Enzyme-Induction, Female, Human, Lymphocytes: en, Male, Middle-Age, Risk, SUPPORT-U-S-GOVT-P-H-S, Variation-(Genetics)

JAX Source

Int J Cancer 1979; 23(3):312-5.

Abstract

We investigated the possible influence of aryl hydrocarbon hydroxylase (AHH) on susceptibility to bladder cancer in humans. AHH inducibility was measured in the cultured lymphocytes of 16 patients who were being followed after successful treatment for bladder cancer, in 53 progeny of bladder cancer patients, and in matched controls. In both the progeny and patient populations, no evidence was found for a difference between the distribution of AHH inducibility or induced AHH activity compared to the distribution among control individuals. Thus, AHH acitivity or inducibility does not appear to be a major determinant of bladder cancer risk in humans.

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