Faculty Research 1970 - 1979

Title

Husbandry of the "nude: mouse in conventional and germfree environments.

Document Type

Article

Publication Date

1975

Keywords

Animals-Newborn, Cesarean-Section, Crosses-Genetic, Environment, Female, Fertility, Germ-Free-Life, Hepatitis-Animal: mo, Heterozygote, Homozygote, Housing-Animal, Lactation, Longevity, Male, Mice, Mice-Nude: gd, ph, Para-Influenza-Virus-Type-1, Pneumonia: mo, ve, Pregnancy, Rodent-Diseases: mo, Selection-(Genetics), SUPPORT-U-S-GOVT-P-H-S, Weaning

JAX Source

Lab-Anim-Sci. 1975 Jun; 25(3):309-14.

Abstract

The "nude: mouse is a unique tool for immunologic studies. Its relatively short life span dictates the application of rigid environmental controls to increase longevity if the mouse is to assume the role of a practical experimental animal. In this paper we discussed the husbandry procedures employed to raise "nude: mice in our facilities under conventional, defined flora, and germfree conditions. Conventional and defined flora mice were raised on laminar flow stay-clean rocks, and germfree "nudes: were housed in self-contained germfree isolators. The major cause of morbidity and mortality among conventional and defined flora "nude: mice was fulminating hepatitis. We presented evidence that the etiologic agent of the disease was mouse hepatitis virus (MHV). Germfree "nude: mice were completely free from viral and bacterial diseases.

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