Faculty Research 1970 - 1979
Evolution of mammalian carbonic anhydrase loci by tanden duplication: close linkage of Car-1 and Car-2 to the centromere region of chromosome 3 of the mouse.
Document Type
Article
Publication Date
1976
Keywords
Animal, Carbonic-Anhydrase, Chromosomes, Crosses-Genetic, Erythrocytes: en, Female, Isoenzymes, Linkage-(Genetics), Male, Mice, Mice-Inbred-Strains, Phenotype, Species-Specificity, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S, Variation-(Genetics)
First Page
651
Last Page
660
JAX Location
41,845
JAX Source
Biochem-Genet. 1976 Aug; 14(7-8):651-60.
Abstract
Electrophoretic variants of two carbonic anhydrase enzymes CAR-1 (CA I) and Car-2 (CA II), have been found in the laboratory mouse, Mus musculus. These two loci are closely linked to each other and are located on chromosome 3 near its centromere. The close linkage of Car-1 and Car-2 supports the hypothesis that the present-day carbonic anhydrase loci are the result of tandem duplication of an earlier carbonic anhydrase locus with subsequent divergence. The red blood cells of mice of the subspecies M.m. casteneus have significantly reduced levels of CAR-1 and CAR-2.
Recommended Citation
Eicher EM,
Stern RH,
Womack JE,
Davisson MT,
Roderick TH,
Reynolds SC.
Evolution of mammalian carbonic anhydrase loci by tanden duplication: close linkage of Car-1 and Car-2 to the centromere region of chromosome 3 of the mouse. Biochem-Genet. 1976 Aug; 14(7-8):651-60.