Faculty Research 1970 - 1979

Title

Liver-specific lysosomal acid phosphatase deficiency (Apl) on mouse chromosome 17.

Document Type

Article

Publication Date

1977

Keywords

Animal, Chromosome-Mapping, Crosses-Genetic, Electrophoresis-Cellulose-Acetate, Female, Genes, H-2-Antigens, Linkage-(Genetics), Liver: en, Lysosomes: en, Male, Mice, Mice-Inbred-Strains, Polymorphism-(Genetics), SUPPORT-U-S-GOVT-P-H-S

JAX Source

Mol-Gen-Genet. 1977 Oct 24; 155(3):315-7.

Abstract

Apl, a gene involved in the processing of lysosomal acid phosphatase in mouse liver, has been mapped on Chromosome 17. The gene order and map distances in per cent recombination of the loci studied are T (20.6 +/- 3.4) Pgk-2 (7.4 +/- 2.2) Apl. Thus, Apl is at least 7 cM distal to H-2 on this chromosome. In addition, strain-specific allelic variants for Apl have been demonstrated on cellulose acetate gels, a quick and inexpensive method of electrophoresis.

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