Faculty Research 1970 - 1979

Title

Relationships between levels of membrane-bound glucuronidase and the associated protein egasyn in mouse tissues.

Document Type

Article

Publication Date

1977

Keywords

Female, Glucuronidase: me, Glycoproteins: bi, Heterozygote, Lysosomes: en, me, Male, Mice, Mice-Inbred-Strains, Microsomes: en, me, Mutation, Organ-Specificity, Radioimmunoassay, SUPPORT-U-S-GOVT-P-H-S, Testosterone

JAX Source

J Cell Biol 1977 Jun; 73(3):728-35.

Abstract

Mouse beta-glucuronidase has a dual intracellular localization, being present in both endoplasmic reticulum and lysosomes of several tissues. Previous studies demonstrated that the protein egasyn is complexed with microsomal but not lysosomal glucuronidase and that a mutant lacking egasyn is deficient in microsomal, but not lysosomal, glucuronidase. By means of a recently developed radioimmunoassay for egasyn, the relationship between microsomal glucuronidase levels and egasyn levels has been examined in various adult tissues, during postnatal development in liver, and after androgen induction of glucuronidase in kidney. The results indicate that the relative availability of egasyn determines the balance between glucuronidase incorporation into membranes and that into lysosomes.

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