Faculty Research 1970 - 1979

Title

An epithelial cell line with chronic polyoma infection established from a spontaneous mouse pancreatic adenocarcinoma.

Document Type

Article

Publication Date

1978

Keywords

Aneuploidy, Animal, C-Type-Viruses: ip, Cell-Line, Female, Inclusion-Bodies-Viral, Male, Mice, Mice-Nude, Mycoplasma: ip, Neoplasm-Transplantation, Neoplasms-Experimental: mi, Pancreatic-Neoplasms: fg, mi, Polyomaviruses: ip, SUPPORT-U-S-GOVT-P-H-S, Transplantation-Homologous

JAX Source

Cancer-Res. 1978 Apr; 38(4):969-77.

Abstract

The establishment of an epithelial cell line from a mouse pancreatic adenocarcinoma is described. The cell line, designated LTPA, was aneuploid and exhibited many transformed growth properties (rapid growth rate, failure to show density-dependent inhibition of growth, ability to grow in defined medium). A type C oncornavirus was isolated from the culture medium, and electron microscopy also revealed the presence of intracisternal type A particles. LTPA cells carried a persistent polyoma infection which produced only low levels of cytopathic effects. A mycoplasmal contamination was also carried. When injected s.c. into Swiss nu/nu mice, LTPA cells formed ductular structures which were destroyed by inflammatory reactions within 3 weeks.

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