Faculty Research 1990 - 1999

Title

Genomic organization, expression and chromosomal localization of the mouse Slug (Slugh) gene.

Document Type

Article

Publication Date

1998

JAX Source

Biochim Biophys Acta 1998 Nov 26;1443(1-2):251-4

Grant

CA34196/CA/NCI, RO1HD34883/HD/NICHD

Abstract

The Slug gene encodes a zinc finger protein implicated in the generation and migration of neural crest cells in several vertebrate species. Here we describe the genomic organization and chromosomal localization of the mouse Slug (Slugh) gene. The mouse Slug gene consists of three exons spanning approx. 4 kb. Northern blot analysis of RNA isolated from several tissues of adult mice revealed the presence of a single 2.1 kb transcript. The chromosomal location of mouse Slug was determined by interspecific backcross analysis. The mapping results indicated that Slugh is located in the proximal region of mouse chromosome 16.

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