Faculty Research 1990 - 1999

Title

New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo.

Document Type

Article

Publication Date

1997

Keywords

Animal, Blastocyst: me, Chromosome-Mapping, Comparative-Study, DNA-Complementary: ge, Gene-Expression-Regulation, Genes-Structural, Mice: em, ge, me, Molecular-Sequence-Data, Multigene-Family, Oocytes: me, Polymerase-Chain-Reaction, Protein-Serine-Threonine-Kinases: bi, ge, Sequence-Alignment, Sequence-Homology-Amino-Acid, Signal-Transduction, Subtraction-Technique, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Mol Reprod Dev 1997 Jun;47(2):148-56

Grant

R01CA37225/CA/NCI, P30CA34196/CA/NCI

Abstract

The initial phase of mammalian preimplantation development is directed by stored maternal mRNAs and their encoded proteins, yet most of the molecules controlling this process have not been described. We have used differential display analysis of cDNA libraries prepared from unfertilized eggs and preimplantation embryos to isolate three maternal cDNAs that represent novel genes exhibiting different patterns of expression during this developmental period. One of these, Melk, encodes a protein with a kinase catalytic domain and a leucine zipper motif, a new member of the Snf1/AMPK family of kinases. This gene product may play a role in the signal transduction events in the egg and early embryo.

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