Faculty Research 1990 - 1999
New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo.
Document Type
Article
Publication Date
1997
Keywords
Animal, Blastocyst: me, Chromosome-Mapping, Comparative-Study, DNA-Complementary: ge, Gene-Expression-Regulation, Genes-Structural, Mice: em, ge, me, Molecular-Sequence-Data, Multigene-Family, Oocytes: me, Polymerase-Chain-Reaction, Protein-Serine-Threonine-Kinases: bi, ge, Sequence-Alignment, Sequence-Homology-Amino-Acid, Signal-Transduction, Subtraction-Technique, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
First Page
148
Last Page
156
JAX Source
Mol Reprod Dev 1997 Jun;47(2):148-56
Grant
R01CA37225/CA/NCI, P30CA34196/CA/NCI
Abstract
The initial phase of mammalian preimplantation development is directed by stored maternal mRNAs and their encoded proteins, yet most of the molecules controlling this process have not been described. We have used differential display analysis of cDNA libraries prepared from unfertilized eggs and preimplantation embryos to isolate three maternal cDNAs that represent novel genes exhibiting different patterns of expression during this developmental period. One of these, Melk, encodes a protein with a kinase catalytic domain and a leucine zipper motif, a new member of the Snf1/AMPK family of kinases. This gene product may play a role in the signal transduction events in the egg and early embryo.
Recommended Citation
Heyer BS,
Warsowe J,
Solter D,
Knowles BB,
Ackerman SL.
New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo. Mol Reprod Dev 1997 Jun;47(2):148-56