Title

Naive application of permutation testing leads to inflated type I error rates.

Document Type

Article

Publication Date

2008

Keywords

Models-Statistical, Research-Design

JAX Source

Genetics 2008 Jan; 178(1):609-10.

Abstract

Failure to account for family structure within populations or in complex mating designs via uninformed applications of permutation testing will lead to inflated type I error rates. Careful consideration of the design factors is essential since some situations allow several valid permutation strategies, and the choice that maximizes statistical power will not always be intuitive.