Title

From ER to Eph receptors: new roles for VAP fragments.

Document Type

Article

Publication Date

2008

Keywords

Animals, Humans, Receptors-Eph-Family, Signal-Transduction, Vesicular-Transport-Proteins

JAX Source

Cell 2008 Jun; 133(6):949-51.

Abstract

Dominantly inherited mutations in an endoplasmic reticulum protein called VAPB have been found in a subset of patients with a rare familial form of amyotrophic lateral sclerosis (ALS). In this issue, Tsuda et al. (2008) identify a secreted form of VAPB that binds directly to Eph receptors inducing their activation and signaling, providing fresh insights into ALS pathogenesis, including non-neuronal aspects of this disorder.