From ER to Eph receptors: new roles for VAP fragments.
Document Type
Article
Publication Date
2008
Keywords
Animals, Humans, Receptors-Eph-Family, Signal-Transduction, Vesicular-Transport-Proteins
First Page
949
Last Page
951
JAX Source
Cell 2008 Jun; 133(6):949-51.
Abstract
Dominantly inherited mutations in an endoplasmic reticulum protein called VAPB have been found in a subset of patients with a rare familial form of amyotrophic lateral sclerosis (ALS). In this issue, Tsuda et al. (2008) identify a secreted form of VAPB that binds directly to Eph receptors inducing their activation and signaling, providing fresh insights into ALS pathogenesis, including non-neuronal aspects of this disorder.
Recommended Citation
Ackerman SL,
Cox GA.
From ER to Eph receptors: new roles for VAP fragments. Cell 2008 Jun; 133(6):949-51.
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