Title

Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes.

Document Type

Article

Publication Date

2009

Keywords

Artemisinins, Chloroquine, Disease-Models-Animal, Erythrocytes, Humans, Interleukin-Receptor-Common-gamma-Subunit, Kinetics, Malaria-Falciparum, Mice-Inbred-NOD, Mice-SCID, Pyridones, Pyrimethamine

JAX Location

see Reprint Collection (a pdf is available)

JAX Source

Antimicrob Agents Chemother 2009 Oct; 53(10):4533-6.

Abstract

Murine models of Plasmodium falciparum malaria may become crucial tools in drug discovery. Here we show that non-myelodepleted NOD-scid IL2Rgamma(null) mice engrafted with human erythrocytes support an infectious burden up to tenfold higher than that supported by engrafted NOD-scid beta2microglobulin(null) mice. The new model was validated for drug discovery and was used to assess the therapeutic efficacy of 4-pyridones, selective inhibitors of P. falciparum cytochrome bc1.

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