Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes.
Document Type
Article
Publication Date
2009
Keywords
Artemisinins, Chloroquine, Disease-Models-Animal, Erythrocytes, Humans, Interleukin-Receptor-Common-gamma-Subunit, Kinetics, Malaria-Falciparum, Mice-Inbred-NOD, Mice-SCID, Pyridones, Pyrimethamine
First Page
4533
Last Page
4536
JAX Location
see Reprint Collection (a pdf is available)
JAX Source
Antimicrob Agents Chemother 2009 Oct; 53(10):4533-6.
Abstract
Murine models of Plasmodium falciparum malaria may become crucial tools in drug discovery. Here we show that non-myelodepleted NOD-scid IL2Rgamma(null) mice engrafted with human erythrocytes support an infectious burden up to tenfold higher than that supported by engrafted NOD-scid beta2microglobulin(null) mice. The new model was validated for drug discovery and was used to assess the therapeutic efficacy of 4-pyridones, selective inhibitors of P. falciparum cytochrome bc1.
Recommended Citation
Jimenez DM,
Mulet T,
Viera S,
Gomez V,
Garuti H,
Ibanez J,
Alvarez DA,
Shultz LD,
Martinez A,
Gargallo VD,
Angulo BI.
Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes. Antimicrob Agents Chemother 2009 Oct; 53(10):4533-6.