Title

Human dendritic cells subsets as targets and vectors for therapy.

Document Type

Article

Publication Date

5-2013

Keywords

Animals, Antigens, CD14, CD8-Positive T-Lymphocytes, Dendritic Cells, Genetic Therapy, Genetic Vectors, Homeostasis, Humans, Interleukin-10, Interleukin-15, Langerhans Cells, Mice, Neoplasms, Skin, T-Lymphocytes, Cytotoxic

JAX Source

Ann NY Acad Sci 2013 May; 1284:24-30

PMID

23651190

Abstract

The skin immune system includes a complex network of dendritic cells (DCs). In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms that maintain immune homeostasis and in pathogenic chronic inflammation in which immune responses are unrestrained. Harnessing DC function by directly targeting DC-derived molecules or by selectively modulating DC subsets is a novel strategy for ameliorating inflammatory diseases. In this short review, we discuss recent advances in understanding the functional specialization of skin DCs and the potential implication for future DC-based therapeutic strategies. Ann NY Acad Sci 2013 May; 1284:24-30