Human dendritic cells subsets as targets and vectors for therapy.
Document Type
Article
Publication Date
5-2013
Keywords
Animals, Antigens, CD14, CD8-Positive T-Lymphocytes, Dendritic Cells, Genetic Therapy, Genetic Vectors, Homeostasis, Humans, Interleukin-10, Interleukin-15, Langerhans Cells, Mice, Neoplasms, Skin, T-Lymphocytes, Cytotoxic
JAX Source
Ann NY Acad Sci 2013 May; 1284:24-30
Volume
1284
First Page
24
Last Page
30
ISSN
1749-6632
PMID
23651190
Abstract
The skin immune system includes a complex network of dendritic cells (DCs). In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms that maintain immune homeostasis and in pathogenic chronic inflammation in which immune responses are unrestrained. Harnessing DC function by directly targeting DC-derived molecules or by selectively modulating DC subsets is a novel strategy for ameliorating inflammatory diseases. In this short review, we discuss recent advances in understanding the functional specialization of skin DCs and the potential implication for future DC-based therapeutic strategies. Ann NY Acad Sci 2013 May; 1284:24-30
Recommended Citation
Klechevsky E,
Banchereau J.
Human dendritic cells subsets as targets and vectors for therapy. Ann NY Acad Sci 2013 May; 1284:24-30