Title

Mouse Tumor Biology (MTB): a database of mouse models for human cancer.

Document Type

Article

Publication Date

1-28-2015

JAX Source

Nucleic Acids Res 2015 Jan 28; 43(Database issue):D818-24.

PMID

25332399

Grant

CA034196, CA089713

Abstract

The Mouse Tumor Biology (MTB; http://tumor.informatics.jax.org) database is a unique online compendium of mouse models for human cancer. MTB provides online access to expertly curated information on diverse mouse models for human cancer and interfaces for searching and visualizing data associated with these models. The information in MTB is designed to facilitate the selection of strains for cancer research and is a platform for mining data on tumor development and patterns of metastases. MTB curators acquire data through manual curation of peer-reviewed scientific literature and from direct submissions by researchers. Data in MTB are also obtained from other bioinformatics resources including PathBase, the Gene Expression Omnibus and ArrayExpress. Recent enhancements to MTB improve the association between mouse models and human genes commonly mutated in a variety of cancers as identified in large-scale cancer genomics studies, provide new interfaces for exploring regions of the mouse genome associated with cancer phenotypes and incorporate data and information related to Patient-Derived Xenograft models of human cancers. Nucleic Acids Res 2015 Jan 28; 43(Database issue):D818-24.