Gene for neuraminidase activity on mouse chromosome 17 near h-2: pleiotropic effects on multiple hydrolases.
Document Type
Article
Publication Date
4-3-1981
Keywords
Alleles, Animals, Chromosome Mapping, Female, H-2 Antigens, Hydrolases, Liver, Major Histocompatibility Complex, Male, Mice, Mice, Inbred Strains, Neuraminidase, Protein Precursors, Recombination, Genetic, Sialic Acids
Abstract
The low activity of liver neuraminidase that is characteristic of mouse strain SM/J is inherited as a single gene on chromosome 17, near the major histocompatibility complex. This gene, neuraminidase-1 (Neu-1), is represented by the low activity allele Neu-1s in SM/J and the high activity allele Neu-1b in C57BL/6J and most other strains. Previously described variations in the posttranslational processing of acid phosphatase, alpha-mannosidase, arylsulfatase-B, and alpha-glucosidase are attributed to pleiotropic effects of this gene.