Faculty Research 1970 - 1979

Strain differences in aryl hydrocarbon hydroxylase induction by 3-methylcholanthrene in rabbits.

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Aryl-Hydrocarbon-Hydroxylases: bi, Crosses-Genetic, Enzyme-Induction, Female, Genotype, Liver: en, Male, Methylcholanthrene, Organ-Weight, Rabbits, Sex-Factors, SUPPORT-U-S-GOVT-P-H-S

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Proc-Soc-Exp-Biol-Med. 1975 Jun; 149(2):526-9.


We determined both basal and induced AHH activity in livers of six partially inbred strains of rabbits. Strain III rabbits had the highest enzyme activity upon induction by 3-MCA, i.e., four to five times that in strain WH (noninducible), which has the lowest enzyme activity. AHH induction was also "low: in strains X, OS, ACEP, and AC. F1 hybrids between strains III and WH revealed a differential response to the induction of liver AHH activity by MCA: the levels of induced hydroxylase activity were consistently higher in (III X WH)F1 rabbits than in the reciprocal (WH X III)F1 hybrids. All possible crosses between these two "extreme: strains are now being analyzed to estimate the number of genes involved in their response difference to MCA.

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