Faculty Research 1970 - 1979
Defective erythropoietic responses of aged mice not improved by young marrow.
Anemia-Aplastic: fg, th, Animal, Bloodletting, Bone-Marrow: cy, tr, Erythropoiesis, Female, Hematopoietic-Stem-Cells: ph, Mice, Mice-Inbred-C57BL, SUPPORT-U-S-GOVT-P-H-S, Transplantation-Homologous
J-Gerontol. 1975 May; 30(3):286-8.
Defective responses to severe bleeding in 25-mo.-old C57BL/6J mice were not improved by injections of 8-mo.-old marrow cells. Such injections greatly improved responses of genetically anemic W/W-v mice that have defective erythropoietic stem cells. Apparently the defective responses of old mice were not intrinsic to their erythropoietic stem cells.
Defective erythropoietic responses of aged mice not improved by young marrow. J-Gerontol. 1975 May; 30(3):286-8.