Defective erythropoietic responses of aged mice not improved by young marrow.
Anemia-Aplastic: fg, th, Animal, Bloodletting, Bone-Marrow: cy, tr, Erythropoiesis, Female, Hematopoietic-Stem-Cells: ph, Mice, Mice-Inbred-C57BL, SUPPORT-U-S-GOVT-P-H-S, Transplantation-Homologous
J-Gerontol. 1975 May; 30(3):286-8.
Defective responses to severe bleeding in 25-mo.-old C57BL/6J mice were not improved by injections of 8-mo.-old marrow cells. Such injections greatly improved responses of genetically anemic W/W-v mice that have defective erythropoietic stem cells. Apparently the defective responses of old mice were not intrinsic to their erythropoietic stem cells.
Harrison, D E., " Defective erythropoietic responses of aged mice not improved by young marrow." (1975). Faculty Research 1970 - 1979. 564.