Antibody-induced killing in vivo of L1210/MTX-R cells quantitated in passively immunized mice with 131I-iododeoxyuridine-labeled cells and whole-body measurement of retained radioactivity.

Authors

G A. Carlson
G Terres

Document Type

Article

Publication Date

1976

Keywords

Antibodies-Neoplasm, Cell-Survival, Complement: me, Cytotoxicity-Tests-Immunologic, Female, Idoxuridine, IgG, IgM, Immunity-Active: re, Immunization-Passive, Immunotherapy, Kinetics, Leukemia-L1210: im, th, Mercaptoethanol, Mice, Radiation-Effects, SUPPORT-U-S-GOVT-P-H-S

First Page

822

Last Page

829

JAX Source

J-Immunol. 1976 Sep; 117(3):822-9.

Abstract

The killing of the LR subline of the DBA/2J leukemia L1210/MTX by passive antibody was followed in vivo with 131I-iododeoxyuridine-labeled cells and whole-body measurement of retained radioactivity. The in vivo killing of LR cells was proportional to the in vitro 2-mercaptoethanol resistant titer, independent of the complement system, and radioresistant. Although a large percentage of the leukemic cells was killed in passively immunized mice, the protective effect of the passive antiserum was dependent on the active immune response of the host.

Recommended Citation

Carlson GA, Terres G. Antibody-induced killing in vivo of L1210/MTX-R cells quantitated in passively immunized mice with 131I-iododeoxyuridine-labeled cells and whole-body measurement of retained radioactivity. J-Immunol. 1976 Sep; 117(3):822-9.