Faculty Research 1970 - 1979
Questionable relation of aryl hydrocarbon hydroxylase to lung-cancer risk.
Document Type
Article
Publication Date
1977
Keywords
Aged, Aryl-Hydrocarbon-Hydroxylases: bi, bl, me, Cells-Cultured, DNA, Enzyme-Induction, Female, Human, Lung-Neoplasms: en, et, ge, Lymphocytes: en, me, Male, Middle-Age, Risk, SUPPORT-U-S-GOVT-P-H-S
First Page
346
Last Page
350
JAX Source
N Engl J Med 1977 Aug 18; 297(7):346-50.
Abstract
To test whether the genetically determined trait, aryl hydrocarbon hydroxylase inducibility, affects susceptibility to lung cancer, we measured this trait in cultured lymphocytes from a normal population, patients with lung cancer and progeny of such patients. We found very low aryl hydrocarbon hydroxylase activity (19 per cent of normal) in about half the patients with lung cancer. Only part of this activity can be accounted for by reduced cell growth and by reduced protein synthesis. In an indirect assessment of inducibility, both 57 progeny and 27 matched controls had a mean inducibility of 2.95 and a similar distribution into low, intermediate and high groups (chi-square = 0.3 P = 0.9). No differences in basal or induced activity were observed. Thus, if patients with lung cancer possess altered aryl hydrocarbon hydroxylase inducibility or activity these characteristics are not transmitted to their progeny.
Recommended Citation
Paigen B,
Gurtoo HL,
Minowada J,
Houten L,
Vincent R,
Paigen K,
Parker NB,
Ward E,
Hayner NT.
Questionable relation of aryl hydrocarbon hydroxylase to lung-cancer risk. N Engl J Med 1977 Aug 18; 297(7):346-50.