Alteration of islet cell populations in spontaneously diabetic mice.
Diabetes-Mellitus: me, pa, ve, Disease-Models-Animal, Fluorescent-Antibody-Technic, Glucagon: me, Insulin: me, Islands-of-Langerhans: me, pa, Mice, Mice-Inbred-C57BL, Mice-Obese, Obesity-in-Diabetes: me, pa, Peptides: me, Somatostatin: me, SUPPORT-U-S-GOVT-P-H-S
Diabetes. 1978 Jan; 27(1):1-7.
Endocrine-cell populations in the islets of Langerhans of mutant mice with a severe hypoinsulinemic diabetes (ob/ob or db/db on the C57BL/KsJ background) or with a mild hyperinsulinemic diabetes (ob/ob or db/db on the C57BL/6J background) were studied quantitatively by immunofluorescence and morphometry. In severely diabetic mice, islets presented a reduced proportion of insulin containing cells but increased glucagon-, somatostatin-, and pancreatic polypeptide (PP)-containing cells, as compared with islets of control (+/+) mice. An inverse change was observed in islets of mildly diabetic mice: islets were hypertrophic and composed mostly of insulin-containing cells, with decreased proportions of glucagon-, somatostatin-, and PP-containing cells. In both types of diabetic syndromes, the changes in cell populations induced a qualitative alteration of cellular interrelationships in the affected islets.
Baetens, D; Stefan, Y; Ravazzola, M; Malaisse, Lagae F.; Coleman, D L.; and Orci, L, " Alteration of islet cell populations in spontaneously diabetic mice." (1978). Faculty Research 1970 - 1979. 845.